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The authors propose here the new 5R principle, which considers the R ight species, R ight place, R ight time, R ight level, and R ight target. Erythrocytes are organelle-free cells that do not possess mitochondria and peroxisomes

Collectively, this study establishes PMP as a novel probiotic metabolite that directly eliminates pathogens and resolving gut microbiome-host metabolic dysregulation

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Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to -lactam antibiotics